Article

Initiation of primary T cell—B cell interactions and early antibody responses in an organized microphysiological model of the human lymph node

2025-01-15

Abstract excerpt

<h4>ABSTRACT</h4> In vitro microphysiological systems (MPS) are needed to replicate events in the lymph node (LN) leading to humoral immunity against new immune threats, but current lymphoid MPS focus largely on recall responses from memory lymphocytes. Here, an LN MPS was developed from primary, naïve human lymphocytes in microfluidic 3D culture to model interactions and antibody production at the LN T cell—B ce...

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Literature Corpus work: 52fcbcc4-ca33-5399-88a1-74d7f8ac6790
DOI: 10.1101/2025.01.12.632545

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