A comparative mathematical modeling study of phenotypic approaches to T cell activation.

Abstract excerpt

T cells use their T cell antigen receptors (TCRs) to recognize peptides presented by major histocompatibility complex molecules (pMHC). These peptides may be low-affinity self-peptides or high-affinity foreign peptides from pathogens. Despite recognizing a broad range of affinities, TCRs trigger significant immune responses only to strongly binding foreign peptides. The mechanisms enabling T cells to distinguish...

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