Article

A Minimal Model Framework for Robust CAR-T Cell and Oncolytic Virus Combination Therapy

2026-01-27

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma remains one of the most lethal brain cancers. Combination therapy using CAR-T cells and oncolytic viruses shows promise, yet the mechanisms underlying synergy remain poorly understood. We develop mathematical models to analyze IL-13R$\alpha$2-targeting CAR-T cells and the oncolytic virus C134 using patient-derived glioblastoma data. We present a minimal model framework for...

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Literature Corpus work: caaa3f1b-5c32-57c3-8b7a-863e1fb5b337
DOI: 10.21203/rs.3.rs-8680401/v1

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