Article

Dynamic estimation of metabolic state during CAR T cell production and the relationship of early metabolism to final therapeutic product

2025-05-13

Abstract excerpt

Adoptive cell therapies such as CAR T cells have revolutionized cancer treatment and shown successes even with refractory cases of haematological malignancies. There is burgeoning interest in the optimization and improved manufacturing of cell therapy products. For CAR T cell therapy, enrichment of certain phenotypes of T cells in the infusion product have been correlated with improved long-term treatment outcomes...

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Literature Corpus work: 76a4f8d0-dc69-53c4-9c18-349e53d31654
DOI: 10.1101/2025.05.11.653250

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