Article

Dynamic mechanisms of time-of-day-dependent adaptive immunity and vaccination responses

2025-05-23

Abstract excerpt

The timing of vaccine administration during the day significantly affects immunogenicity and efficacy, yet the mechanism governing the time-of-day dependent adaptive immunity and vaccine response remains elusive. Using mathematical modeling, we elucidate that the bistability arising from the self-enhancing homing process of antigen-presenting dendritic cells plays a key role in the time-of-day-dependent adaptive i...

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Literature Corpus work: 80fffab1-76a1-55f0-8aa7-20707a04f711
DOI: 10.1101/2025.05.19.654803

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