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Viral mimicry and memory deficits upon microglial deletion of ATRX

2024-05-08

Abstract excerpt

The importance of chromatin-mediated processes in neurodevelopmental and intellectual disability disorders is well recognised. However, how chromatin dysregulation in glial cells impacts cognitive abilities is less well understood. Here, we demonstrate that targeted loss of the ATRX chromatin remodeler in microglia alters chromatin accessibility profiles, leading to the de-repression of endogenous retroelements, t...

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Literature Corpus work
a7a79161-97be-5b60-82b1-e6023fafa17e
DOI
10.1101/2024.05.07.592875
Open publication

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Viral mimicry and memory deficits upon microglial deletion of ATRXDOI 10.1101/2024.05.07.592875
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