Article

The Nerve Growth Factor IB-like Receptor Nurr1 (NR4A2) Recruits CoREST Transcription Repressor Complexes to Silence HIV Following Proviral Reactivation in Microglial Cells

2021-11-16

Abstract excerpt

<h4>ABSTRACT</h4> Human immune deficiency virus (HIV) infection of microglial cells in the brain leads to chronic neuroinflammation, which is antecedent to the development of HIV-associated neurocognitive disorders (HAND) in the majority of patients. Productively HIV infected microglia release multiple neurotoxins including proinflammatory cytokines and HIV proteins such as envelope glycoprotein (gp120) and trans...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16963cb9-c85d-58dc-a94b-b0924557ff63
DOI: 10.1101/2021.11.16.468784

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Nerve Growth Factor IB-like Receptor Nurr1 (NR4A2) Recruits CoREST Transcription Repressor Complexes to Silence HIV Following Proviral Reactivation in Microglial CellsDOI 10.1101/2021.11.16.468784Read

HIV-1 infection of human microglia activates inflammatory pathways associated with HIV-associated neurocognitive disorders (HAND)Semantic proximity Read

Regulation of HIV-1 gene transcription: from lymphocytes to microglial cellsSemantic proximity Read

Transcriptional Mapping of Neuro-Immune Interactions during Homeostasis and HIV infection using Microglia-containing Human Cerebral AssembloidsSemantic proximity Read

Comparative Analysis of Human Microglial Models for Studies of HIV Replication and PathogenesisSemantic proximity Read

Neuroinflammation and EIF2 signaling persist in an HiPSC tri-culture model of HIV infection despite antiretroviral treatmentSemantic proximity Read

Opioid-induced immunosuppression of brain myeloid cells in SIV-infected rhesus macaquesSemantic proximity Read

Dysregulated neuroimmune interactions and sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoidsSemantic proximity Read

STAT1-Mediated Regulation of IL-17A/CEBPB/NF-κB Axis in HIV-1 Infected Human Cerebral Organoids Reveals Therapeutic Targets for NeuroprotectionSemantic proximity Read

Single-cell analysis of antiviral neuroinflammatory responses in the mouse dorsal raphe nucleusSemantic proximity Read

Microglia and macrophages alterations in the CNS during acute SIV infection: a single-cell analysis in rhesus macaquesSemantic proximity Read

Single cell RNA sequencing reveals a novel, microglia-like cell type in cerebrospinal fluid during virologically suppressed HIVSemantic proximity Read

The sounds of silencing: dynamic epigenetic control of HIV latencySemantic proximity Read