Article

Activation of endogenous retroviruses during brain development causes neuroinflammation

2020-07-08

Abstract excerpt

Endogenous retroviruses (ERVs) make up a large fraction of mammalian genomes and are thought to contribute to human disease, including brain disorders. In the brain, aberrant activation of ERVs is a potential trigger for neuroinflammation, but mechanistic insight into this phenomenon remains lacking. Using CRISPR/Cas9-based gene disruption of the epigenetic co-repressor protein Trim28, we found a dynamic H3K9me3-d...

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Literature Corpus work: 7c8dd0f9-5a27-5272-9a27-2a57382f1d88
DOI: 10.1101/2020.07.07.191668

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