Article

ATRX Deficiency Drives Aberrant Type I Interferon Signalling Through cGAS-Dependent Transcriptional Dysregulation

2025-11-21

Abstract excerpt

<h4>ABSTRACT</h4> The X-linked α-thalassaemia intellectual disability syndrome (ATRX) protein is a chromatin remodeller involved in transcriptional regulation and genome stability. While the importance of ATRX in development and malignancy is well recognised, its role in innate immunity is less well defined. In two unrelated patients demonstrating cerebral white matter disease, learning difficulties and a persist...

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Literature Corpus work: a9b06a22-6f5e-5b1a-88b4-47b6bd1740b3
DOI: 10.1101/2025.11.19.685761

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