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Article

Persistent DNA damage promotes microglial dysfunction in Ataxia-telangiectasia

2021-06-02

Abstract excerpt

<h4>ABSTRACT</h4> The autosomal recessive genome instability disorder Ataxia-telangiectasia, caused by mutations in ATM kinase, is characterised by the progressive loss of cerebellar neurons. We find that DNA damage associated with ATM loss results in dysfunctional behaviour of human microglia, immune cells of the central nervous system. Microglial dysfunction is mediated by the pro-inflammatory RELB/p52 non-cano...

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Literature Corpus work
936c992c-abd3-5101-af22-37b1a1b4ad05
DOI
10.1101/2021.06.02.446712
Open publication

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Persistent DNA damage promotes microglial dysfunction in Ataxia-telangiectasiaDOI 10.1101/2021.06.02.446712
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