Article

Haploid mouse germ cell precursors from embryonic stem cells reveal <i>Xist</i> activation from a single X chromosome

2020-10-30

Abstract excerpt

<h4>Summary</h4> Mammalian haploid cells have applications for genetic screening and substituting gametic genomes. Here we characterize a culture system for obtaining haploid primordial germ cell-like cells (PCGLCs) from haploid mouse embryonic stem cells (ESCs). We find that a haploid genome is maintained in PGCLCs with a high frequency indicating a substantially lower rate of diploidization than somatic cells....

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Literature Corpus work: a7a35007-479e-5a68-8e35-9c9c8a18a7bb
DOI: 10.1101/2020.10.30.361915

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