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Article

Enhancer-associated H3K4 methylation safeguards in vitro germline competence.

Nature communications - 1 Oct 2021

Bleckwehl Tore, Crispatzu Giuliano, Schaaf Kaitlin, Respuela Patricia, Bartusel Michaela, Benson Laura, Clark Stephen J, Dorighi Kristel M, Barral Antonio, Laugsch Magdalena, van IJcken Wilfred F J, Manzanares Miguel, Wysocka Joanna, Reik Wolf, Rada-Iglesias Álvaro

Abstract excerpt

Germline specification in mammals occurs through an inductive process whereby competent cells in the post-implantation epiblast differentiate into primordial germ cells (PGC). The intrinsic factors that endow epiblast cells with the competence to respond to germline inductive signals remain unknown. Single-cell RNA sequencing across multiple stages of an in vitro PGC-like cells (PGCLC) differentiation system...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34599190
DOI: 10.1038/s41467-021-26065-6
PMCID: PMC8486853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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