Article

PTPN22 Regulates T Cell Synapse Formation through PSTPIP1- Dependent Actin Remodeling

2025-04-26

Abstract excerpt

Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a critical regulator of T cell signaling, working in concert with C-terminal SRC kinase (Csk) to dephosphorylate key signaling proteins and suppress lymphocyte activation. The R620W variant of PTPN22, one of the most prevalent mutations associated with autoimmune diseases, has been implicated in altered T cell responses, although its broader effects on...

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Literature Corpus work: a7909b8d-abfd-5a4d-8fbf-d53d16fdfd35
DOI: 10.1101/2025.04.24.650379

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