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Article

The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages.

Blood - 24 Apr 2014

Starnes Taylor W, Bennin David A, Bing Xinyu, Eickhoff Jens C, Grahf Daniel C, Bellak Jason M, Seroogy Christine M, Ferguson Polly J, Huttenlocher Anna

Abstract excerpt

PSTPIP1 is a cytoskeletal adaptor and F-BAR protein that has been implicated in autoinflammatory disease, most notably in the PAPA syndrome: pyogenic sterile arthritis, pyoderma gangrenosum, and acne. However, the mechanism by which PSTPIP1 regulates the actin cytoskeleton and contributes to disease pathogenesis remains elusive. Here, we show that endogenous PSTPIP1 negatively regulates macrophage podosome...

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Source

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Identifiers

PMID: 24421327
DOI: 10.1182/blood-2013-07-516948
PMCID: PMC3999755

Genes

PSTPIP1
SRC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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