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Article

Proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1) controls immune synapse stability in human T cells.

The Journal of allergy and clinical immunology - 1 Dec 2018

Janssen Willemijn J M, Grobarova Valeria, Leleux Jardin, Jongeneel Lieneke, van Gijn Marielle, van Montfrans Joris M, Boes Marianne

Abstract excerpt

BACKGROUND: Proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1) is a cytosolic adaptor protein involved with T-cell activation, differentiation, and migration. On cognate T-cell contact, PSTPIP1 is recruited to surface-expressed CD2, where it regulates F-actin remodeling. An immune synapse (IS) is thereby rapidly formed, consisting of T-cell receptor clusters surrounded by a ring of adhesion...

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Source

Identifiers

PMID: 29432774
DOI: 10.1016/j.jaci.2018.01.030

Genes

PSTPIP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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