Article

Butyrophilin 2A2 promotes T cell immunoregulation by enhancing CD45 phosphatase activity within the immune synapse

2024-11-15

Abstract excerpt

<h4>ABSTRACT</h4> B7 costimulatory family member Butyrophilin 2A2 ( BTN2A2) is predominantly expressed by antigen presenting cells and regulates T cell immunity, but molecular mechanisms are unclear. Using immunoblots analyzing TCR-initiated signaling intermediaries, co-immunoprecipitation studies, confocal microscopy, structural modeling-guided mutational analyses, and microscale thermophoresis, we demonstrate...

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Literature Corpus work: a00115d1-e11a-5207-917a-8c2f13901acc
DOI: 10.1101/2024.11.12.623303

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