Article

PAG orchestrates T cell immune synapse function by binding to actin

2024-12-03

Abstract excerpt

Many immunotherapies impact T cell function by impacting the immune synapse. While immunotherapy is extremely successful in some patients, in many others, it fails to help or causes complications, including immune-related adverse events. Phosphoprotein Associated with Glycosphingolipid Rich Microdomains 1 (PAG) is a transmembrane scaffold protein with importance in T cell signaling. PAG has 10 tyrosine phosphoryla...

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Literature Corpus work: d29278d3-daab-598d-ad2c-602c6e8a61f8
DOI: 10.1101/2024.11.29.625440

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