Article

Phostensin Enables Lymphocyte Integrin Activation and Population of Peripheral Lymphoid Organs

2021-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Rap1 GTPase drives assembly of the Mig-10/RIAM/lamellipodin–Integrin–Talin (MIT) complex that enables integrin-dependent lymphocyte functions. Here we used tandem affinity tag-based proteomics to isolate and analyze the MIT complex and reveal that Phostensin (PTSN), a regulatory subunit of protein phosphatase 1, is a component of the complex. PTSN mediates de-phosphorylation of Rap1 thereby pres...

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Literature Corpus work: 9f6e023b-9fca-507e-8905-f2e389050730
DOI: 10.1101/2021.09.24.461584

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