Article

Multivalent adaptor networks generate nanoscale organisation within T cell signalling condensates

2026-04-30

Abstract excerpt

Ligand engagement of the T cell receptor (TCR) triggers phosphorylation-dependent assembly of signalling complexes at the plasma membrane, yet how these assemblies are organised to coordinate signal propagation remains unclear. Here, using quantitative super-resolution imaging in primary human T cells, we show that phosphorylated TCR (pTCR) and linker for activation of T cells (pLAT) reside within micrometre-scale...

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Identifiers and source

Literature Corpus work: 30e89394-49a6-5826-96c2-519b85cdea38
DOI: 10.64898/2026.04.28.721251

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