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<i>Shank3</i> establishes AMPA receptor subunit composition at cerebellar mossy fiber-granule cell synapses and shapes regional microglia activation

2025-08-01

Abstract excerpt

Mutations in Shank3 are the primary genetic cause of Phelan-McDermid Syndrome (PMS), a neurodevelopmental disorder frequently comorbid with autism spectrum disorder (ASD). As a key scaffolding protein in the postsynaptic site, SHANK3 is critical for excitatory glutamatergic synapse function by interacting with AMPARs, NMDARs, and mGluRs. While Shank3 deficiency has been extensively studied in forebrain regions,...

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Literature Corpus work
85b56f82-96e5-56c6-9af1-44f1225d650f
DOI
10.1101/2025.08.01.668222
Open publication

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<i>Shank3</i> establishes AMPA receptor subunit composition at cerebellar mossy fiber-granule cell synapses and shapes regional microglia activationDOI 10.1101/2025.08.01.668222
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