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Article

Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 May 2012

Yang Mu, Bozdagi Ozlem, Scattoni Maria Luisa, Wöhr Markus, Roullet Florence I, Katz Adam M, Abrams Danielle N, Kalikhman David, Simon Harrison, Woldeyohannes Leuk, Zhang James Y, Harris Mark J, Saxena Roheeni, Silverman Jill L, Buxbaum Joseph D, Crawley Jacqueline N

Abstract excerpt

Mutations in the synaptic scaffolding protein gene SHANK3 are strongly implicated in autism and Phelan-McDermid 22q13 deletion syndrome. The precise location of the mutation within the Shank3 gene is key to its phenotypic outcomes. Here, we report the physiological and behavioral consequences of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22573675
DOI: 10.1523/JNEUROSCI.6107-11.2012
PMCID: PMC3362928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22573675-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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