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Preserved social development but impaired executive function in a <i>Shank3</i> -deficient rat model of Phelan-McDermid syndrome

2026-08-18

Abstract excerpt

<h4>ABSTRACT</h4> Phelan-McDermid syndrome (PMS) is a genetic neurodevelopmental disorder caused by a microdeletion within chromosome 22q13.3 1–6 , and accounts for ∼1-3% of cases of autism spectrum disorders (ASD). Individuals with PMS typically present with neonatal hypotonia, severe speech delay, intellectual disability, motor impairments, and autism-related features, although additional manifestations such a...

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Literature Corpus work
fa01eeac-7c75-5fcd-8bff-e0e49d200389
DOI
10.64898/2026.08.13.744651
Open publication

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Preserved social development but impaired executive function in a <i>Shank3</i> -deficient rat model of Phelan-McDermid syndromeDOI 10.64898/2026.08.13.744651
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