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Article

Juvenile Shank3b deficient mice present with behavioral phenotype relevant to autism spectrum disorder.

Behavioural brain research - 1 Jan 2019

Balaan Chantell, Corley Michael J, Eulalio Tiffany, Leite-Ahyo Ka'ahukane, Pang Alina P S, Fang Rui, Khadka Vedbar S, Maunakea Alika K, Ward Monika A

Abstract excerpt

Autism spectrum disorder (ASD) is a pervasive, multifactorial neurodevelopmental disorder diagnosed according to deficits in three behavioral domains: communication, social interaction, and stereotyped/repetitive behaviors. Mutations in Shank genes account for ∼1% of clinical ASD cases with Shank3 being the most common gene variant. In addition to maintaining synapses and facilitating dendritic maturation, Shank...

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Identifiers

PMID: 30134148
DOI: 10.1016/j.bbr.2018.08.005
PMCID: PMC6247805

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