Article
Major motor and gait deficits with sexual dimorphism in a Shank3 mutant mouse model.
Molecular autism - 19 Jan 2021
Matas Emmanuel, Maisterrena Alexandre, Thabault Mathieu, Balado Eric, Francheteau Maureen, Balbous Anais, Galvan Laurie, Jaber Mohamed
Abstract excerpt
BACKGROUND: Contrasting findings were reported in several animal models with a Shank3 mutation used to induce various autism spectrum disorder (ASD) symptoms. Here, we aimed at investigating behavioral, cellular, and molecular consequences of a C-terminal (frameshift in exon 21) deletion in Shank3 protein in mice, a mutation that is also found in clinical conditions and which results in loss of major isoforms of...
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