Article

Single cell RNA sequencing reveals limited effects of Lrrk2 genotype in a mouse model of acute CNS inflammation

2025-12-22

Abstract excerpt

<h4>BACKGROUND</h4> Previous data implicates neuroinflammation in the pathogenesis of Parkinson’s disease (PD). Of the genes associated with PD, Leucine rich repeat kinase 2 (LRRK2) has previously been proposed to play a role in neuroinflammation. However, the extent to which LRRK2 is involved in endogenous inflammatory signaling is unclear. <h4>OBJECTIVE</h4> To examine whether endogenous mutations in LRRK2 aff...

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Literature Corpus work: a74dd684-304f-5086-85fc-5a20f256cde5
DOI: 10.64898/2025.12.18.695199

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