Article

Short-term lipopolysaccharide treatment leads to astrocyte activation in LRRK2 G2019S knock-in mice without loss of dopaminergic neurons

2024-03-21

Abstract excerpt

<title>Abstract</title> <p>Background The G2019S mutation of LRRK2, which enhances kinase activity of the protein, confers a substantial risk of developing Parkinson’s disease (PD). However, the mutation demonstrates incomplete penetrance, suggesting the involvement of other genetic or environmental modulating factors. Here, we investigated whether LRRK2 G2019S knock-in (KI) mice treated with the inflammogen lip...

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Literature Corpus work: 8d95a7b0-bc49-5752-ae9b-5d71b691d8e8
DOI: 10.21203/rs.3.rs-4076333/v1

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