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Article

Leucine-rich repeat kinase 2 modulates cyclooxygenase 2 and the inflammatory response in idiopathic and genetic Parkinson's disease.

Neurobiology of aging - 1 May 2014

Lopez de Maturana Rakel, Aguila Julio C, Sousa Amaya, Vazquez Nerea, Del Rio Patricia, Aiastui Ana, Gorostidi Ana, Lopez de Munain Adolfo, Sanchez-Pernaute Rosario

Abstract excerpt

Inflammatory mechanisms are activated in aging and late-onset neurodegenerative diseases, such as Parkinson's disease (PD). Mutations in leucine-rich repeat kinase 2 (LRRK2) contribute to both idiopathic and familial forms of PD. Here, we investigated the involvement of LRRK2 in inflammatory pathways using primary dermal fibroblasts from patients with 2 common mutations in LRRK2 (G2019S and R1441G), idiopathic PD...

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Source

Identifiers

PMID: 24360742
DOI: 10.1016/j.neurobiolaging.2013.11.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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