Article

Engineering Functionality Optimized fully human B7-H3 CAR T Cells for Enhanced Solid Tumor Therapy

2026-01-09

Abstract excerpt

<h4>SUMMARY</h4> B7-H3 is a cell surface protein overexpressed in many solid tumors and an attractive target for chimeric antigen receptor (CAR) T cell therapy. The most clinically advanced B7-H3 CARs are derived from murine monoclonal antibodies (mAbs) 376.96 and MGA271, which are now in phase 1/11 trials. However, non-human mAb sequences can provoke immune responses, leading to CAR T-cell rejection and therape...

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Literature Corpus work: a7384c83-0b35-57ea-9462-721bf1929e99
DOI: 10.64898/2026.01.09.696281

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