Article

Combinatorial T cell engineering eliminates on-target off-tumor toxicity of CD229 CAR T cells while maintaining anti-tumor activity

2021-12-07

Abstract excerpt

<h4>ABSTRACT</h4> T cells expressing chimeric antigen receptors have shown remarkable therapeutic activity against different types of cancer. However, their wider use has been hampered by the potential for life-threatening toxicities due to the unintended targeting of healthy cells expressing low levels of the targeted antigen. We have now developed an affinity-tuning approach for the generation of minimally modi...

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Literature Corpus work: 8d70c44c-a706-581b-9c5e-f94db3cda0f6
DOI: 10.1101/2021.12.06.471279

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Combinatorial T cell engineering eliminates on-target off-tumor toxicity of CD229 CAR T cells while maintaining anti-tumor activityDOI 10.1101/2021.12.06.471279Read

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