Article

Universal Dual-Target CAR-γδT Cells Targeting B7-H3 and IL13Rα2 for Glioblastoma Therapy

2025-05-16

Abstract excerpt

Glioblastoma (GBM) represents the most prevalent and aggressive primary malignant neoplasm in the adult central nervous system, exhibiting marked infiltrative growth patterns, inevitable recurrence, and dismal therapeutic outcomes with current treatment modalities. While CAR-T cell immunotherapy has demonstrated remarkable success in hematological malignancies, its clinical translation for GBM has been hampered by...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d1aa626-2066-553e-be4f-a53f59ff1642
DOI: 10.1101/2025.05.14.653035

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Universal Dual-Target CAR-γδT Cells Targeting B7-H3 and IL13Rα2 for Glioblastoma TherapyDOI 10.1101/2025.05.14.653035Read

Selective IL13Rα2-Targeted Functionality of IL13-Ligand CARs is Enhanced by Inclusion of 4-1BB Co-StimulationSemantic proximity Read

Highly potent novel multi-armoured IL13Ra2 CAR-T subverts the immunosuppressive microenvironment of GlioblastomaSemantic proximity Read

Suppression of human glioma xenografts with second-generation IL13R-specific chimeric antigen receptor-modified T cells.Semantic proximity Read

Allogeneic CAR T Cells: An Alternative to Overcome Challenges of CAR T Cell Therapy in GlioblastomaSemantic proximity Read

Design of a novel NanoCAR construct that compares well with a conventional ScFv-based CAR targeting BCMA on multiple myelomaSemantic proximity Read

PTPRZ1-targeting RNA CAR-T cells exert antigen-specific and bystander antitumor activity in glioblastomaSemantic proximity Read

A Bi-Specific T Cell-Engaging Antibody Triggers Protective Immune Memory and Glioma Microenvironment Remodeling in Immune Competent Preclinical ModelsSemantic proximity Read

Characterization and Functional Analysis of scFv-based Chimeric Antigen Receptors to Redirect T Cells to IL13Rα2-positive GliomaSemantic proximity Read

Pooled screening for CAR function identifies novel IL13Rα2-targeted CARs for treatment of glioblastomaSemantic proximity Read

In vivo DNA-launched bispecific T cell engager targeting IL-13Rα2 controls tumor growth in an animal model of glioblastoma multiformeSemantic proximity Read

A novel CAR T cell blend targeting PDPN and GD2 to overcome glioblastoma heterogeneitySemantic proximity Read

Efficient multiplex non-viral engineering and expansion of polyclonal γδ CAR-T cells for immunotherapySemantic proximity Read