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B7-H3 in Pediatric Tumors: Far beyond Neuroblastoma

21 Jun 2023

Abstract excerpt

B7-H3 is a 4Ig transmembrane protein that emerged as a tumor-associated antigen in neuroblastoma. It belongs to the B7 family, shows an immunoregulatory role toward NK and T cells, and, therefore, has been included in the growing family of immune checkpoints. Besides neuroblastoma, B7-H3 is expressed by many pediatric cancers including tumors of the central nervous system, sarcomas, and acute myeloid leukemia. In...

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PMID: 37444389
DOI: 10.3390/cancers15133279

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