Article

The anti-B7-H3 blocking antibody MJ18 does not recognize B7-H3 in murine tumor models

2023-11-17

Abstract excerpt

The immune checkpoint molecule B7-H3 is regarded as one of the most promising therapeutic targets for the treatment of human cancers. B7-H3 is highly expressed in many cancers and its expression has been associated to impaired antitumor immunity and poor patient prognosis. In immunocompetent mouse tumor models, genetic deletion of B7-H3 in tumor cells enhances antitumor immune response leading to tumor shrinkage....

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Literature Corpus work: f74b3ada-9002-5964-9aff-38af97a64022
DOI: 10.1101/2023.11.15.567261

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