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Multivalent, Bispecific <i>α</i> B7-H3- <i>α</i> CD3 Chemically Self-Assembled Nanorings Direct Potent T-cell Responses Against Medulloblastoma

2022-03-17

Abstract excerpt

Few therapeutic options have been made available for treating central nervous system tumors, especially upon recurrence. Recurrent medulloblastoma is uniformly lethal with no approved therapies. Recent preclinical studies have shown promising results for eradicating various solid tumors by targeting the overexpressed immune checkpoint molecule, B7-H3. However, due to several therapy-related toxicities and reports...

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Literature Corpus work
d945e4f9-4a37-57c1-8a3e-9eb18e590803
DOI
10.1101/2022.03.15.484517
Open publication

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Multivalent, Bispecific <i>α</i> B7-H3- <i>α</i> CD3 Chemically Self-Assembled Nanorings Direct Potent T-cell Responses Against MedulloblastomaDOI 10.1101/2022.03.15.484517
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