Article

ITC-6102RO, A Novel B7-H3 Antibody-Drug Conjugate, Exhibits Potent Therapeutic Effects against B7-H3 Expressing Solid Tumors

2023-05-25

Abstract excerpt

<h4>Background: </h4> The B7-H3 protein, encoded by the CD276 gene, is a member of the B7 family of proteins and a transmembrane glycoprotein. It is highly expressed in various solid tumors, such as lung and breast cancer, and has been associated with limited expression in normal tissues and poor clinical outcomes across different malignancies. Additionally, B7-H3 plays a crucial role in anticancer immune response...

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Literature Corpus work: eb76fa1c-8ae9-515d-b1fc-e9815c36a141
DOI: 10.21203/rs.3.rs-2969459/v1

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