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Article

Structure and Cancer Immunotherapy of the B7 Family Member B7x

30 Oct 2014

Abstract excerpt

B7x (B7-H4 or B7S1) is a member of the B7 family that can inhibit T cell function. B7x protein is absent in most normal human tissues and immune cells, but it is overexpressed in human cancers and often correlates with negative clinical outcome. The expression pattern and function of B7x suggest that it may be a potent immunosuppressive pathway in human cancers. Here, we determined the crystal structure of the...

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Identifiers

PMID: 25437562
DOI: 10.1016/j.celrep.2014.09.053

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