Back to search

Article

B7-H3 specific CAR-T cells exhibit potent activity against prostate cancer

2023-01-24

Abstract excerpt

<title>Abstract</title><p>The high expression across multiple solid tumor, including prostate cancer and restricted expression in normal tissues makes B7-H3 an attractive target for immunotherapy. Among various types of tumor immunotherapy, chimeric antigen receptor T (CAR-T) cell therapy has shown remarkable success in hematological tumors. However, the potency of CAR-T cell therapy in solid tumors is still limit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c8989692-bfb3-5c9b-9d28-0ddfab9bd9fd
DOI
10.21203/rs.3.rs-2487141/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
B7-H3 specific CAR-T cells exhibit potent activity against prostate cancerDOI 10.21203/rs.3.rs-2487141/v1
The Inhibitory Role of B7-H4 in Antitumor Immunity: Association with Cancer Progression and SurvivalSemantic proximity
A multifunctional T-cell engager containing CD80 enhances prostate cancer treatmentSemantic proximity
B7x—from bench to bedsideSemantic proximity
Integrative molecular analyses define the genomic, transcriptomic, and epigenomic correlates of high B7-H3 expression in metastatic castrate-resistant prostate cancerSemantic proximity
Integrative molecular analyses define correlates of high B7-H3 expression in metastatic castrate-resistant prostate cancerSemantic proximity
ITC-6102RO, A Novel B7-H3 Antibody-Drug Conjugate, Exhibits Potent Therapeutic Effects against B7-H3 Expressing Solid TumorsSemantic proximity
The third group of the B7‐ CD 28 immune checkpoint family: HHLA 2, TMIGD 2, B7x, and B7‐H3Semantic proximity
Large-scale analysis reveals the specific clinical and immune features of B7-H3 in gliomaSemantic proximity
To kill a cancer: Targeting the immune inhibitory checkpoint molecule, B7-H3Semantic proximity
Deciphering the suppressive immune microenvironment of prostate cancer based on CD4+ regulatory T cells: Implications for prognosis and therapy predictionSemantic proximity
Nuclear overexpression levels of MAGE-A3 predict poor prognosis in patients with prostate cancerSemantic proximity
New B7 Family Checkpoints in Human CancersSemantic proximity
Select a neighboring publication to make it the new centre.