Article

WDR76 promotes MLL-rearranged leukemia via selective recognition of 5-hydroxymethylcytosine in DNA

2019-01-03

Abstract excerpt

<h4>SUMMARY</h4> Although rare, the distribution of the 5-hydroxymethylcytosine (hmC) modification in mammalian DNA is tissue- and gene-specific, yet distinct from its transcriptionally-repressive methylcytosine (mC) precursor, suggesting unique signaling potential. To examine this possibility, we fractionated mammalian brain extracts to discover binding partners specific for oxidized states of mC. We demonstrate...

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Literature Corpus work: a72c5d06-5e87-56c7-8895-e2e9aee4fab4
DOI: 10.1101/511394

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