Article

Targeting H3K4 methylation as a novel therapeutic strategy against tumor infiltration and nuclear changes of acute lymphoblastic leukemia cells

2022-06-17

Abstract excerpt

<h4>Summary</h4> Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, and the infiltration of leukemic cells is critical for disease progression and relapse. In spite of the canonical functions of histone methylation in gene regulation, differentiation, and DNA homeostasis; its contribution to the nuclear deformability of migrating leukemic cells remains unclear. Here, we showed that 3D conditi...

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Literature Corpus work: 03b79ebe-5f2c-5c43-bc86-f96972eaa05e
DOI: 10.1101/2022.06.16.495903

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