Article

Aberrant splicing of <i>MBD1</i> reshapes the epigenome to drive convergent myeloerythroid defects in MDS

2025-10-19

Abstract excerpt

Myelodysplastic neoplasms (MDS) feature hematopoietic deficits driven in part by transcript splicing abnormalities. Thus far, such disease-driving transcripts have been identified in association with specific splicing factor mutations. However, it remains unclear whether there also exists a set of disease-wide conserved pathological transcripts, which drive MDS independently of mutational status. Here, we characte...

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Identifiers and source

Literature Corpus work: 141378fb-13a9-5bad-87a1-7d8ee1fd8014
DOI: 10.1101/2025.10.17.682569

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