Article

DNA hypohydroxymethylation in pediatric central nervous system tumors is associated with CTCF binding sites and reduced survival

2020-06-23

Abstract excerpt

Nucleotide-specific 5-hydroxymethylcytosine (5hmC) remains understudied in pediatric central nervous system tumors. We measured genome-scale 5hmC in glioma, ependymoma, and embryonal tumors from children, as well as control pediatric brain tissues using oxidative and bisulfite treatments. Tumor 5hmC localized to regulatory elements crucial to cell identity, including transcription factor binding sites and super-en...

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Literature Corpus work: 87b67d12-4a3d-5147-b45b-d43bb3c5e6b9
DOI: 10.1101/2020.06.20.20136184

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