Article

<i>Kdm6a</i> Deficiency Restricted to Mouse Hematopoietic Cells Causes an Age- and Sex-dependent Myelodysplastic Syndrome-Like Phenotype

2021-08-04

Abstract excerpt

<h4> Abstract </h4> Kdm6a/Utx , a gene on the X chromosome, encodes a histone K27me3 demethylase that has an orthologue on the Y chromosome ( Uty )[1]. We previously identified inactivating mutations of Kdm6a in approximately 50% of mouse acute promyelocytic leukemia samples; however, somatic mutations of KDM6A are more rare in human AML samples, ranging in frequency from 2-15% in different series of patients...

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Literature Corpus work: 36d75218-3006-5fa3-94cd-723f89ab5412
DOI: 10.1101/2021.08.04.455117

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