Article

<i>In Vivo</i> Multiplexed Modeling Reveals Diverse Roles of the TBX2 Subfamily and <i>Egr1</i> in <i>Ras</i> -Driven Lung Adenocarcinoma

2025-03-17

Abstract excerpt

The TBX2 subfamily of T-box transcription factors (including Tbx2 , Tbx3 , Tbx4 , Tbx5 ) plays an essential role in lung development. Downregulation of these genes in human Lung adenocarcinoma (LUAD) suggests that these genes may be tumor suppressive, however because downregulation appears to occur primarily via epigenetic change, it remains unclear if these changes causally drive tumor progression or are mere...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a6f039c4-610d-515b-b587-ca62c82e5785
DOI: 10.1101/2025.03.15.642187

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>In Vivo</i> Multiplexed Modeling Reveals Diverse Roles of the TBX2 Subfamily and <i>Egr1</i> in <i>Ras</i> -Driven Lung AdenocarcinomaDOI 10.1101/2025.03.15.642187Read

Molecular architecture of the tumor microenvironment caused by <i>BRCA1</i> and <i>BRCA2</i> somatic mutations in lung adenocarcinomaSemantic proximity Read

A cellular and spatial atlas of <i>TP53</i> -associated tissue remodeling in lung adenocarcinomaSemantic proximity Read

A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung CancerSemantic proximity Read

Comprehensive pan-cancer analysis identifies H2AFX associated with poor prognosis in lung adenocarcinomaSemantic proximity Read

Genetic determinants of <i>EGFR</i> -Driven Lung Cancer Growth and Therapeutic Response <i>In Vivo</i>Semantic proximity Read

<i>In vivo</i> CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancerSemantic proximity Read

A Lung Cancer Mouse Model DatabaseSemantic proximity Read

Integrative multi-omic sequencing reveals the MMTV-Myc mouse model mimics human breast cancer heterogeneitySemantic proximity Read

Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies <i>B2M</i> Inactivation Impairing ImmunorecognitionSemantic proximity Read

Systematic In Vivo Inactivation of Chromatin-Regulating Enzymes Identifies Setd2 as a Potent Tumor Suppressor in Lung Adenocarcinoma.Semantic proximity Read

Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation.Semantic proximity Read

Optimized iMAP CRISPR Perturbation Illuminates the Context-Specific Functions of RNA Modification FactorsSemantic proximity Read