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<i>In vivo</i> CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

2022-03-13

Abstract excerpt

How the genetic landscape of a tumor governs the tumor’s response to immunotherapy remains largely elusive. Here, we established a direct in vivo CRISPR/Cas9 gene editing methodology to assess the immune-modulatory capabilities of 573 putative cancer genes associated with altered cytotoxic activity in human cancers. Using Kras G12D - and Braf V600E -driven mouse lung cancer models, we identify Serpinb9 and Ad...

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Literature Corpus work
5d693e57-7f0c-505e-a13c-3b36fc1a45f3
DOI
10.1101/2022.03.13.484176
Open publication

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<i>In vivo</i> CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancerDOI 10.1101/2022.03.13.484176
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