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Article

Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation.

Cell stem cell - 6 Mar 2025

England Frances J, Bordeu Ignacio, Ng Minn-E, Bang JaeHak, Kim Bumsoo, Choi Jinwook, Cardoso Erik C, Koo Bon-Kyoung, Simons Benjamin D, Lee Joo-Hyeon

Abstract excerpt

Disruptions to regulatory signals governing stem cell fate open the pathway to tumorigenesis. To determine how these programs become destabilized, we fate-map thousands of murine wild-type and KrasG12D-mutant alveolar type II (AT2) stem cells in vivo and find evidence for two independent AT2 subpopulations marked by distinct tumorigenic capacities. By combining clonal analyses with single-cell transcriptomics, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39978341
DOI: 10.1016/j.stem.2025.01.011
PMCID: PMC13432921

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