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Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies <i>B2M</i> Inactivation Impairing Immunorecognition

2016-12-22

Abstract excerpt

Purpose: We aimed to maximize the performance of detecting genetic alterations in lung cancer using high-throughput sequencing for patient-derived xenografts (PDXs). Experimental Design: We undertook an integrated RNA and whole-exome sequencing of 14 PDXs. We focused on the genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex. Results: We identified alterations in genes...

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Literature Corpus work
8c6bc856-c41b-52da-acd4-02176bcb1827
DOI
10.1158/1078-0432.ccr-16-1946-t
Open publication

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Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies <i>B2M</i> Inactivation Impairing ImmunorecognitionDOI 10.1158/1078-0432.ccr-16-1946-t
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