Article

Molecular architecture of the tumor microenvironment caused by <i>BRCA1</i> and <i>BRCA2</i> somatic mutations in lung adenocarcinoma

2026-02-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Homologous recombination repair (HRR) deficiency is associated with improved immunotherapy responses in non-small cell lung cancer (NSCLC) patients. The HRR genes BRCA1 / 2 are key regulators of DNA repair, yet their impact on the tumor microenvironment (TME) in lung adenocarcinoma (LUAD) remains unclear. <h4>Methods</h4> Using single-cell sequencing and multi-omics data...

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Literature Corpus work: 8f536111-1615-5cb2-831a-1c7a09ebb445
DOI: 10.64898/2026.01.29.702641

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