Article

A cellular and spatial atlas of <i>TP53</i> -associated tissue remodeling in lung adenocarcinoma

2023-06-29

Abstract excerpt

<h4>ABSTRACT</h4> TP53 is the most frequently mutated gene across many cancers and is associated with shorter survival in lung adenocarcinoma (LUAD). To define how TP53 mutations affect the LUAD tumor microenvironment (TME), we constructed a multi-omic cellular and spatial tumor atlas of 23 treatment-naïve human lung tumors. We found that TP53 -mutant ( TP53 mut ) malignant cells lose alveolar identity and upr...

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Literature Corpus work: beac4fab-bc82-556d-a91a-bec2ffee0530
DOI: 10.1101/2023.06.28.546977

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