Article

Human GINS : a conserved DNA replication factor and candidate cancer marker

2010-01-01

Abstract excerpt

The GINS complex (a heterotetramer of Sld5, Psf1, Psf2 and Psf3) is a highly conserved DNA replication factor required for the initiation and elongation of DNA replication. GINS is believed to associate with Cdc45 and MCM proteins on replicating DNA. The interaction between GINS and MCM is also conserved in archaea. In my thesis, I explore the subcellular localisation of the GINS complex in relation to the MCM pro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a6beb12e-d6bf-590a-bd50-03a769c03a31
DOI: 10.17863/cam.16510

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human GINS : a conserved DNA replication factor and candidate cancer markerDOI 10.17863/cam.16510Read

Crystal structure of the GINS complex and functional insights into its role in DNA replication.Semantic proximity Read

Drosophila Sld5 is essential for normal cell cycle progression and maintenance of genomic integrity.Semantic proximity Read

GINS inactivation phenotypes reveal two pathways for chromatin association of replicative alpha and epsilon DNA polymerases in fission yeast.Semantic proximity Read

The MCM Complex: Its Role in DNA Replication and Implications for Cancer TherapySemantic proximity Read

Drosophila Psf2 has a role in chromosome condensation.Semantic proximity Read

MCM proteins as diagnostic and prognostic tumor markers in the clinical setting.Semantic proximity Read

Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiencySemantic proximity Read

Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.Semantic proximity Read

HOXD13 Binds DNA Replication Origins To Promote Origin Licensing and Is Inhibited by GemininSemantic proximity Read

Cdc45 is limiting for replication initiation in humansSemantic proximity Read

Treslin and its role in the assembly of the replicative DNA helicaseSemantic proximity Read

Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombinationSemantic proximity Read