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HOXD13 Binds DNA Replication Origins To Promote Origin Licensing and Is Inhibited by Geminin

25 Aug 2009

Abstract excerpt

HOX DNA-binding proteins control patterning during development by regulating processes such as cell aggregation and proliferation. Recently, a possible involvement of HOX proteins in replication origin activity was suggested by results showing that a number of HOX proteins interact with the DNA replication licensing regulator geminin and bind a characterized human origin of replication. The functional...

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Identifiers

PMID: 19703996
DOI: 10.1128/mcb.00509-09

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