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Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination

31 Dec 2015

Abstract excerpt

We have recently identified lens epithelium-derived growth factor (LEDGF/p75, also known as PSIP1) as a component of the homologous recombination DNA repair machinery. Through its Pro-Trp-Trp-Pro (PWWP) domain, LEDGF/p75 binds to histone marks associated with active transcription and promotes DNA end resection by recruiting DNA endonuclease retinoblastoma-binding protein 8 (RBBP8/CtIP) to broken DNA ends. Here we...

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PMID: 26721387
DOI: 10.1093/nar/gkv1526

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